Second Opinion features an exclusive set of "Z-missions", which are gradually unlocked as the player progresses through the main campaign. Instruments are also streamlined, with some items such as bandages only appearing when neccessary. A new instrument exclusive to the Wii version is the defibrilator, replacing the heart massage, which requires players to use both the Wii Remote and Nunchuk to resuscitate patients. Players use the Wii Remote to utilise each of the instruments, whilst the Nunchuk is used to quickly select instruments. Trauma Center: Second Opinion builds upon the DS version with enhanced graphics, new controls, and additional content. Trauma Center: Second Opinion is a Wii game, the fifty-fourth game played by Danny and Arin, and the 126th series on Game Grumps. Trauma Center: Second Opinion - Instant CLASSIC! Arin and Dan.
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